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Strong Selection Significantly Increases Epistatic Interactions in the Long-Term Evolution of a Protein
Epistatic interactions between residues determine a protein’s adaptability and shape its evolutionary trajectory. When a protein experiences a changed environment, it is under strong selection to find a peak in the new fitness landscape. It has been shown that strong selection increases epistatic in...
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| Izdano u: | PLoS Genet |
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| Glavni autori: | , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Public Library of Science
2016
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4814079/ https://ncbi.nlm.nih.gov/pubmed/27028897 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005960 |
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