Isoindolone derivative QSN-10c induces leukemic cell apoptosis and suppresses angiogenesis via PI3K/AKT signaling pathway inhibition

AIM: 2-(4,6-Dimethoxy-1,3-dioxoisoindolin-2-yl) ethyl 2-chloroacetate (QSN-10c) is one of isoindolone derivatives with antiproliferative activity against human umbilical vein endothelial cells (HUVECs). The aim of this study was to investigate its antitumor activity in vitro and anti-angiogenic effe...

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Détails bibliographiques
Publié dans:Acta Pharmacol Sin
Auteurs principaux: Lv, Wen-wen, Qin, Si-ning, Chen, Cong-qin, Zhang, Jin-jie, Ren, Tian-shu, Xu, Yong-nan, Zhao, Qing-chun
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2014
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4814032/
https://ncbi.nlm.nih.gov/pubmed/24786233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2013.194
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