Practical utilization of recombinant AAV vector reference standards: focus on vector genomes titration by free ITR qPCR

Clinical trials using recombinant adeno-associated virus (rAAV) vectors have demonstrated efficacy and a good safety profile. Although the field is advancing quickly, vector analytics and harmonization of dosage units are still a limitation for commercialization. AAV reference standard materials (RS...

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Pubblicato in:Mol Ther Methods Clin Dev
Autori principali: D’Costa, Susan, Blouin, Veronique, Broucque, Frederic, Penaud-Budloo, Magalie, François, Achille, Perez, Irene C, Le Bec, Christine, Moullier, Philippe, Snyder, Richard O, Ayuso, Eduard
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4813604/
https://ncbi.nlm.nih.gov/pubmed/27069952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtm.2016.19
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