Myeloid Acyl-CoA:Cholesterol Acyltransferase 1 Deficiency Reduces Lesion Macrophage Content and Suppresses Atherosclerosis Progression

Acyl-CoA:cholesterol acyltransferase 1 (Acat1) converts cellular cholesterol to cholesteryl esters and is considered a drug target for treating atherosclerosis. However, in mouse models for atherosclerosis, global Acat1 knockout (Acat1(−/−)) did not prevent lesion development. Acat1(−/−) increased a...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Huang, Li-Hao, Melton, Elaina M., Li, Haibo, Sohn, Paul, Rogers, Maximillian A., Mulligan-Kehoe, Mary Jo, Fiering, Steven N., Hickey, William F., Chang, Catherine C. Y., Chang, Ta-Yuan
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2016
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4813549/
https://ncbi.nlm.nih.gov/pubmed/26801614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.713818
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