Deletion of Mbtps1 (Pcsk8, S1p, Ski-1) Gene in Osteocytes Stimulates Soleus Muscle Regeneration and Increased Size and Contractile Force with Age

Conditional deletion of Mbtps1 (cKO) protease in bone osteocytes leads to an age-related increase in mass (12%) and in contractile force (30%) in adult slow twitch soleus muscles (SOL) with no effect on fast twitch extensor digitorum longus muscles. Surprisingly, bone from 10–12-month-old cKO animal...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Gorski, Jeff P., Huffman, Nichole T., Vallejo, Julian, Brotto, Leticia, Chittur, Sridar V., Breggia, Anne, Stern, Amber, Huang, Jian, Mo, Chenglin, Seidah, Nabil G., Bonewald, Lynda, Brotto, Marco
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Gene Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4813460/
https://ncbi.nlm.nih.gov/pubmed/26719336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.686626
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