Sialic acid-modified antigens impose tolerance via inhibition of T-cell proliferation and de novo induction of regulatory T cells

Sialic acids are negatively charged nine-carbon carboxylated monosaccharides that often cap glycans on glycosylated proteins and lipids. Because of their strategic location at the cell surface, sialic acids contribute to interactions that are critical for immune homeostasis via interactions with sia...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Perdicchio, Maurizio, Ilarregui, Juan M., Verstege, Marleen I., Cornelissen, Lenneke A. M., Schetters, Sjoerd T. T., Engels, Steef, Ambrosini, Martino, Kalay, Hakan, Veninga, Henrike, den Haan, Joke M. M., van Berkel, Lisette A., Samsom, Janneke N., Crocker, Paul R., Sparwasser, Tim, Berod, Luciana, Garcia-Vallejo, Juan J., van Kooyk, Yvette, Unger, Wendy W. J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2016
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4812702/
https://ncbi.nlm.nih.gov/pubmed/26941238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1507706113
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