Glycan modification of antigen alters its intracellular routing in dendritic cells, promoting priming of T cells

Antigen uptake by dendritic cells and intracellular routing of antigens to specific compartments is regulated by C-type lectin receptors that recognize glycan structures. We show that the modification of Ovalbumin (OVA) with the glycan-structure Lewis(X) (Le(X)) re-directs OVA to the C-type lectin r...

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Udgivet i:eLife
Main Authors: Streng-Ouwehand, Ingeborg, Ho, Nataschja I, Litjens, Manja, Kalay, Hakan, Boks, Martine Annemarie, Cornelissen, Lenneke AM, Kaur Singh, Satwinder, Saeland, Eirikur, Garcia-Vallejo, Juan J, Ossendorp, Ferry A, Unger, Wendy WJ, van Kooyk, Yvette
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2016
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4811763/
https://ncbi.nlm.nih.gov/pubmed/26999763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.11765
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