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Ibrutinib: A paradigm shift in management of CLL
B-cell receptor (BCR) signaling plays a vital role in B-cell malignancies; Bruton's Tyrosine Kinase (BTK) is a critical mediator of this signaling. BCR signaling, either constitutively or following antigen binding, leads to activation of several downstream pathways involved in cell survival, pr...
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| Publicado no: | Expert Rev Hematol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4811630/ https://ncbi.nlm.nih.gov/pubmed/25387837 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1586/17474086.2014.977862 |
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