Ibrutinib: A paradigm shift in management of CLL

B-cell receptor (BCR) signaling plays a vital role in B-cell malignancies; Bruton's Tyrosine Kinase (BTK) is a critical mediator of this signaling. BCR signaling, either constitutively or following antigen binding, leads to activation of several downstream pathways involved in cell survival, pr...

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Detalles Bibliográficos
Publicado en:Expert Rev Hematol
Main Authors: Badar, Talha, Burger, Jan A, Wierda, William G, O'Brien, Susan
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4811630/
https://ncbi.nlm.nih.gov/pubmed/25387837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1586/17474086.2014.977862
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