ATR-Chk1 signaling inhibition as a therapeutic strategy to enhance cisplatin chemosensitivity in urothelial bladder cancer

DNA damage responses contribute to cisplatin resistance; however, therapeutic strategies to overcome cisplatin resistance have not yet been established. Here, we demonstrate that inhibition of ATR-Chk1 pathway with the potent inhibitor WYC0209 sensitizes bladder cancer cells to cisplatin. In the cli...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Li, Ching-Chia, Yang, Juan-Cheng, Lu, Mei-Chin, Lee, Chia-Lin, Peng, Chieh-Yu, Hsu, Wei-Yu, Dai, Yun-Hao, Chang, Fang-Rong, Zhang, Da-Yong, Wu, Wen-Jeng, Wu, Yang-Chang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2015
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4811508/
https://ncbi.nlm.nih.gov/pubmed/26657501
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