Apoptosis induced by a HIPK2 full-length-specific siRNA is due to off-target effects rather than prevalence of HIPK2-Δe8 isoform

Small interfering RNAs (siRNAs) are widely used to study gene function and extensively exploited for their potential therapeutic applications. HIPK2 is an evolutionary conserved kinase that binds and phosphorylates several proteins directly or indirectly related to apoptosis. Recently, an alternativ...

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Publicat a:Oncotarget
Autors principals: Di Rocco, Giuliana, Verdina, Alessandra, Gatti, Veronica, Virdia, Ilaria, Toietta, Gabriele, Todaro, Matilde, Stassi, Giorgio, Soddu, Silvia
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2015
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4811489/
https://ncbi.nlm.nih.gov/pubmed/26625198
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