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Critical role of PPARγ in myeloid-derived suppressor cell-stimulated cancer cell proliferation and metastasis
Lysosomal acid lipase (LAL) is a key enzyme controlling neutral lipid metabolic signaling in myeloid-derived suppressor cells (MDSCs). MDSCs from LAL-deficient (lal(−/−)) mice directly stimulate cancer cell proliferation. PPARγ ligand treatment inhibited lal(−/−) MDSCs stimulation of tumor cell grow...
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| Publicado no: | Oncotarget |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Impact Journals LLC
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4811478/ https://ncbi.nlm.nih.gov/pubmed/26625314 |
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