Targeting PDK1 with dichloroacetophenone to inhibit acute myeloid leukemia (AML) cell growth

Pyruvate dehydrogenase kinase-1 (PDK1), a key metabolic enzyme involved in aerobic glycolysis, is highly expressed in many solid tumors. Small molecule compound DAP (2,2-dichloroacetophenone) is a potent inhibitor of PDK1. Whether targeting PDK1 with DAP can inhibit acute myeloid leukemia (AML) and...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Qin, Lijun, Tian, Yun, Yu, Zhenlong, Shi, Dingbo, Wang, Jingshu, Zhang, Changlin, Peng, Ruoyu, Chen, Xuezhen, Liu, Congcong, Chen, Yiming, Huang, Wenlin, Deng, Wuguo
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4811468/
https://ncbi.nlm.nih.gov/pubmed/26593251
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