Activator of G-protein Signaling 3 (AGS3)-induced lysosomal biogenesis limits macrophage intracellular bacterial infection

Many intracellular pathogens cause disease by subverting macrophage innate immune defense mechanisms. Intracellular pathogens actively avoid delivery to, or directly target lysosomes, the major intracellular degradative organelle. Here, we demonstrate that AGS3 (Activator of G-protein Signaling 3),...

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Pubblicato in:J Immunol
Autori principali: Vural, Ali, Al Khodor, Souhaila, Cheung, Gordon Y.C., Shi, Chong-Shan, Srinivasan, Lalitha, McQuiston, Travis J., Hwang, Il-Young, Yeh, Anthony J., Blumer, Joe B., Briken, Volker, Williamson, Peter R., Otto, Michael, Fraser, Iain D.C., Kehrl, John H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4811337/
https://ncbi.nlm.nih.gov/pubmed/26667172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1501595
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