Activator of G-protein Signaling 3 (AGS3)-induced lysosomal biogenesis limits macrophage intracellular bacterial infection

Many intracellular pathogens cause disease by subverting macrophage innate immune defense mechanisms. Intracellular pathogens actively avoid delivery to, or directly target lysosomes, the major intracellular degradative organelle. Here, we demonstrate that AGS3 (Activator of G-protein Signaling 3),...

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Udgivet i:J Immunol
Main Authors: Vural, Ali, Al Khodor, Souhaila, Cheung, Gordon Y.C., Shi, Chong-Shan, Srinivasan, Lalitha, McQuiston, Travis J., Hwang, Il-Young, Yeh, Anthony J., Blumer, Joe B., Briken, Volker, Williamson, Peter R., Otto, Michael, Fraser, Iain D.C., Kehrl, John H.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4811337/
https://ncbi.nlm.nih.gov/pubmed/26667172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1501595
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