Early lethality and neuronal proteinopathy in mice expressing cytoplasm-targeted FUS that lacks the RNA recognition motif

Mutations to the RNA binding protein, fused in sarcoma (FUS) occur in ~5% of familial ALS and FUS-positive cytoplasmic inclusions are commonly observed in these patients. Altered RNA metabolism is increasingly implicated in ALS, yet it is not understood how the specificity with which FUS interacts w...

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Publicado en:Amyotroph Lateral Scler Frontotemporal Degener
Autores principales: ROBINSON, HANNAH K., DEYKIN, ALEXEY V., BRONOVITSKY, EVGENY V., OVCHINNIKOV, RUSLAN K., USTYUGOV, ALEXEY A., SHELKOVNIKOVA, TATYANA A., KUKHARSKY, MICHAIL S., ERMOLKEVICH, TATYANA G., GOLDMAN, IGOR L., SADCHIKOVA, ELENA R., KOVRAZHKINA, ELENA A., BACHURIN, SERGEY O., BUCHMAN, VLADIMIR L., NINKINA, NATALIA N.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4811325/
https://ncbi.nlm.nih.gov/pubmed/25991062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/21678421.2015.1040994
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