UTX demethylase activity is required for satellite cell–mediated muscle regeneration

The X chromosome–encoded histone demethylase UTX (also known as KDM6A) mediates removal of repressive trimethylation of histone H3 lysine 27 (H3K27me3) to establish transcriptionally permissive chromatin. Loss of UTX in female mice is embryonic lethal. Unexpectedly, male UTX-null mice escape embryon...

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Udgivet i:J Clin Invest
Main Authors: Faralli, Hervé, Wang, Chaochen, Nakka, Kiran, Benyoucef, Aissa, Sebastian, Soji, Zhuang, Lenan, Chu, Alphonse, Palii, Carmen G., Liu, Chengyu, Camellato, Brendan, Brand, Marjorie, Ge, Kai, Dilworth, F. Jeffrey
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4811158/
https://ncbi.nlm.nih.gov/pubmed/26999603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI83239
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