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Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor

Adoptive immunotherapy with regulatory T cells (Tregs) is a promising treatment for allograft rejection and graft-versus-host disease (GVHD). Emerging data indicate that, compared with polyclonal Tregs, disease-relevant antigen-specific Tregs may have numerous advantages, such as a need for fewer ce...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: MacDonald, Katherine G., Hoeppli, Romy E., Huang, Qing, Gillies, Jana, Luciani, Dan S., Orban, Paul C., Broady, Raewyn, Levings, Megan K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4811124/
https://ncbi.nlm.nih.gov/pubmed/26999600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI82771
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