Loss of gastrokine-2 drives premalignant gastric inflammation and tumor progression

Chronic mucosal inflammation is associated with a greater risk of gastric cancer (GC) and, therefore, requires tight control by suppressive counter mechanisms. Gastrokine-2 (GKN2) belongs to a family of secreted proteins expressed within normal gastric mucosal cells. GKN2 expression is frequently lo...

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發表在:J Clin Invest
Main Authors: Menheniott, Trevelyan R., O’Connor, Louise, Chionh, Yok Teng, Däbritz, Jan, Scurr, Michelle, Rollo, Benjamin N., Ng, Garrett Z., Jacobs, Shelley, Catubig, Angelique, Kurklu, Bayzar, Mercer, Stephen, Minamoto, Toshinari, Ong, David E., Ferrero, Richard L., Fox, James G., Wang, Timothy C., Sutton, Philip, Judd, Louise M., Giraud, Andrew S.
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2016
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4811116/
https://ncbi.nlm.nih.gov/pubmed/26974160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI82655
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