Substituting mouse transcription factor Pou4f2 with a sea urchin orthologue restores retinal ganglion cell development

Pou domain transcription factor Pou4f2 is essential for the development of retinal ganglion cells (RGCs) in the vertebrate retina. A distant orthologue of Pou4f2 exists in the genome of the sea urchin (class Echinoidea) Strongylocentrotus purpuratus (SpPou4f1/2), yet the photosensory structure of se...

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Bibliografiske detaljer
Udgivet i:Proc Biol Sci
Main Authors: Mao, Chai-An, Agca, Cavit, Mocko-Strand, Julie A., Wang, Jing, Ullrich-Lüter, Esther, Pan, Ping, Wang, Steven W., Arnone, Maria Ina, Frishman, Laura J., Klein, William H.
Format: Artigo
Sprog:Inglês
Udgivet: The Royal Society 2016
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Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4810862/
https://ncbi.nlm.nih.gov/pubmed/26962139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rspb.2015.2978
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