Flexible Long-Range Loops in the V(H) Gene Region of the Igh Locus Facilitate the Generation of a Diverse Antibody Repertoire

The immunoglobulin heavy-chain (Igh) locus undergoes large-scale contraction in pro-B cells, which facilitates V(H)-DJ(H) recombination by juxtaposing distal V(H) genes next to the DJ(H)-rearranged gene segment in the 3′ proximal Igh domain. By using high-resolution mapping of long-range interaction...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Medvedovic, Jasna, Ebert, Anja, Tagoh, Hiromi, Tamir, Ido M., Schwickert, Tanja A., Novatchkova, Maria, Sun, Qiong, Huis in ‘t Veld, Pim J., Guo, Chunguang, Yoon, Hye Suk, Denizot, Yves, Holwerda, Sjoerd J.B., de Laat, Wouter, Cogné, Michel, Shi, Yang, Alt, Frederick W., Busslinger, Meinrad
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4810778/
https://ncbi.nlm.nih.gov/pubmed/23973221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2013.08.011
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