Pharmacologic Inhibition of Nedd8 Activation Enzyme Exposes CD4-Induced Epitopes within Env on Cells Expressing HIV-1

HIV-1 Vpu decreases the exposure of epitopes within the viral envelope glycoprotein (Env) on the surface of infected cells by downregulating both BST2 and CD4. To test the hypothesis that inhibiting Vpu activity would increase the exposure of these epitopes and sensitize infected cells to antibody-d...

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Bibliographic Details
Published in:J Virol
Main Authors: Tokarev, Andrey, Stoneham, Charlotte, Lewinski, Mary K., Mukim, Amey, Deshmukh, Savitha, Vollbrecht, Thomas, Spina, Celsa A., Guatelli, John
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2016
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4810708/
https://ncbi.nlm.nih.gov/pubmed/26676780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02736-15
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