Pharmacologic Inhibition of Nedd8 Activation Enzyme Exposes CD4-Induced Epitopes within Env on Cells Expressing HIV-1

HIV-1 Vpu decreases the exposure of epitopes within the viral envelope glycoprotein (Env) on the surface of infected cells by downregulating both BST2 and CD4. To test the hypothesis that inhibiting Vpu activity would increase the exposure of these epitopes and sensitize infected cells to antibody-d...

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Vydáno v:J Virol
Hlavní autoři: Tokarev, Andrey, Stoneham, Charlotte, Lewinski, Mary K., Mukim, Amey, Deshmukh, Savitha, Vollbrecht, Thomas, Spina, Celsa A., Guatelli, John
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2016
Témata:
Virus-Cell Interactions
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4810708/
https://ncbi.nlm.nih.gov/pubmed/26676780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02736-15
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