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A Novel Live Pichinde Virus-Based Vaccine Vector Induces Enhanced Humoral and Cellular Immunity after a Booster Dose

Pichinde virus (PICV) is a bisegmented enveloped RNA virus that targets macrophages and dendritic cells (DCs) early in infection and induces strong innate and adaptive immunity in mice. We have developed a reverse genetics system to produce live recombinant PICV (strain P18) with a trisegmented RNA...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:J Virol
Hauptverfasser: Dhanwani, Rekha, Zhou, Yanqin, Huang, Qinfeng, Verma, Vikram, Dileepan, Mythili, Ly, Hinh, Liang, Yuying
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4810697/
https://ncbi.nlm.nih.gov/pubmed/26676795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02705-15
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