Functional Genomics Reveals Linkers Critical for Influenza Virus Polymerase

Influenza virus mRNA synthesis by the RNA-dependent RNA polymerase involves binding and cleavage of capped cellular mRNA by the PB2 and PA subunits, respectively, and extension of viral mRNA by PB1. However, the mechanism for such a dynamic process is unclear. Using high-throughput mutagenesis and s...

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Udgivet i:J Virol
Main Authors: Wang, Lulan, Wu, Aiping, Wang, Yao E., Quanquin, Natalie, Li, Chunfeng, Wang, Jingfeng, Chen, Hsiang-Wen, Liu, Suyang, Liu, Ping, Zhang, Hong, Qin, F. Xiao-Feng, Jiang, Taijiao, Cheng, Genhong
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2016
Fag:
Genome Replication and Regulation of Viral Gene Expression
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4810648/
https://ncbi.nlm.nih.gov/pubmed/26719244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02400-15
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