MicroRNA-Detargeted Mengovirus for Oncolytic Virotherapy

Mengovirus, a member of the Picornaviridae family, has a broad cell tropism and can cause encephalitis and myocarditis in multiple mammalian species. Attenuation has been achieved by shortening the polycytidine tract in the 5′ noncoding region (NCR). A poly(C)-truncated strain of mengovirus, vMC(24)...

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Bibliografiske detaljer
Udgivet i:J Virol
Main Authors: Ruiz, Autumn J., Hadac, Elizabeth M., Nace, Rebecca A., Russell, Stephen J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2016
Fag:
Genome Replication and Regulation of Viral Gene Expression
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4810567/
https://ncbi.nlm.nih.gov/pubmed/26865716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02810-15
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