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Estrogen decreases TNF gene expression by blocking JNK activity and the resulting production of c-Jun and JunD

Central to the bone-sparing effect of estrogen (E(2)) is its ability to block the monocytic production of the osteoclastogenic cytokine TNF-α (TNF). However, the mechanism by which E(2) downregulates TNF production is presently unknown. Transient transfection studies in HeLa cells, an E(2) receptor–...

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Detalhes bibliográficos
Main Authors: Srivastava, Sunil, Weitzmann, M. Neale, Cenci, Simone, Ross, F. Patrick, Adler, Stuart, Pacifici, Roberto
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1999
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC481048/
https://ncbi.nlm.nih.gov/pubmed/10449442
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