Gold nanoparticle conjugated Rad6 inhibitor induces cell death in triple negative breast cancer cells by inducing mitochondrial dysfunction and PARP-1 hyperactivation: Synthesis and characterization

We recently developed a small molecule inhibitor SMI#9 for Rad6, a protein overexpressed in aggressive breast cancers and involved in DNA damage tolerance. SMI#9 induces cytotoxicity in cancerous cells but spares normal breast cells; however, its therapeutic efficacy is limited by poor solubility. H...

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Veröffentlicht in:Nanomedicine
Hauptverfasser: Haynes, Brittany, Zhang, Yanhua, Liu, Fangchao, Li, Jing, Petit, Sarah, Kothayer, Hend, Bao, Xun, Westwell, Andrew D, Mao, Guangzhao, Shekhar, Malathy PV
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4809765/
https://ncbi.nlm.nih.gov/pubmed/26563438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nano.2015.10.010
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