Neo-Epitopes—Fragments of Cartilage and Connective Tissue Degradation in Early Rheumatoid Arthritis and Unclassified Arthritis

OBJECTIVE: Tissue destruction in rheumatoid arthritis (RA) is predominantly mediated by matrix metalloproteinases (MMPs), thereby generating protein fragments. Previous studies have revealed that these fragments include MMP-mediated collagen type I, II, and III degradation, citrullinated and MMP-deg...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Maijer, Karen I., Gudmann, Natasja Stæhr, Karsdal, Morten Asser, Gerlag, Daniëlle M., Tak, Paul Peter, Bay-Jensen, Anne Christine
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4809616/
https://ncbi.nlm.nih.gov/pubmed/27019199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0149329
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