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Role for Cdk1 (Cdc2)/Cyclin A in Preventing the Mammalian Origin Recognition Complex's Largest Subunit (Orc1) from Binding to Chromatin during Mitosis

The eukaryotic origin recognition complex (ORC) selects the genomic sites where prereplication complexes are assembled and DNA replication begins. In proliferating mammalian cells, ORC activity appears to be regulated by reducing the affinity of the Orc1 subunit for chromatin during S phase and then...

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Main Authors: Li, Cong-jun, Vassilev, Alex, DePamphilis, Melvin L.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2004
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC480893/
https://ncbi.nlm.nih.gov/pubmed/15199143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.13.5875-5886.2004
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