Role for Cdk1 (Cdc2)/Cyclin A in Preventing the Mammalian Origin Recognition Complex's Largest Subunit (Orc1) from Binding to Chromatin during Mitosis

The eukaryotic origin recognition complex (ORC) selects the genomic sites where prereplication complexes are assembled and DNA replication begins. In proliferating mammalian cells, ORC activity appears to be regulated by reducing the affinity of the Orc1 subunit for chromatin during S phase and then...

Full description

Saved in:
Bibliographic Details
Main Authors: Li, Cong-jun, Vassilev, Alex, DePamphilis, Melvin L.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2004
Subjects:
Cell Growth and Development
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC480893/
https://ncbi.nlm.nih.gov/pubmed/15199143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.13.5875-5886.2004
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items