Ebselen, a Small-Molecule Capsid Inhibitor of HIV-1 Replication

The human immunodeficiency virus type 1 (HIV-1) capsid plays crucial roles in HIV-1 replication and thus represents an excellent drug target. We developed a high-throughput screening method based on a time-resolved fluorescence resonance energy transfer (HTS-TR-FRET) assay, using the C-terminal doma...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Thenin-Houssier, Suzie, de Vera, Ian Mitchelle S., Pedro-Rosa, Laura, Brady, Angela, Richard, Audrey, Konnick, Briana, Opp, Silvana, Buffone, Cindy, Fuhrmann, Jakob, Kota, Smitha, Billack, Blase, Pietka-Ottlik, Magdalena, Tellinghuisen, Timothy, Choe, Hyeryun, Spicer, Timothy, Scampavia, Louis, Diaz-Griffero, Felipe, Kojetin, Douglas J., Valente, Susana T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4808204/
https://ncbi.nlm.nih.gov/pubmed/26810656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02574-15
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