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Amino Acid Substitutions Account for Most MexS Alterations in Clinical nfxC Mutants of Pseudomonas aeruginosa

Multidrug-resistant mutants of Pseudomonas aeruginosa that overproduce the active efflux system MexEF-OprN (called nfxC mutants) have rarely been characterized in the hospital setting. Screening of 221 clinical strains exhibiting a reduced susceptibility to ciprofloxacin (a substrate of MexEF-OprN)...

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Dettagli Bibliografici
Pubblicato in:Antimicrob Agents Chemother
Autori principali: Richardot, Charlotte, Juarez, Paulo, Jeannot, Katy, Patry, Isabelle, Plésiat, Patrick, Llanes, Catherine
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4808181/
https://ncbi.nlm.nih.gov/pubmed/26833155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02622-15
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