Contribution of Gag and Protease to HIV-1 Phenotypic Drug Resistance in Pediatric Patients Failing Protease Inhibitor-Based Therapy

Protease inhibitors (PIs) are used as a first-line regimen in HIV-1-infected children. Here we investigated the phenotypic consequences of amino acid changes in Gag and protease on lopinavir (LPV) and ritonavir (RTV) susceptibility among pediatric patients failing PI therapy. The Gag-protease from i...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Giandhari, Jennifer, Basson, Adriaan E., Sutherland, Katherine, Parry, Chris M., Cane, Patricia A., Coovadia, Ashraf, Kuhn, Louise, Hunt, Gillian, Morris, Lynn
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4808165/
https://ncbi.nlm.nih.gov/pubmed/26833162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02682-15
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