Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine.

Deficient hydroxylation of debrisoquine is an autosomal recessive trait that affects approximately 7% of the Caucasian population. These individuals (poor metabolizers) carry deficient CYP2D6 gene variants and have an impaired metabolism of severely commonly used drugs. The opposite phenomenon also...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Johansson, I, Lundqvist, E, Bertilsson, L, Dahl, M L, Sjöqvist, F, Ingelman-Sundberg, M
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC48077/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7903454/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.24.11825
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