Targeted p53 activation by saRNA suppresses human bladder cancer cells growth and metastasis

BACKGROUND: Previous study showed that dsP53-285 has the capacity to induce tumor suppressor gene p53 expression by targeting promoter in non-human primates’ cells. And it is well known that TP53 gene is frequently mutant or inactivated in human bladder cancer. Hereby, whether this small RNA can act...

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Библиографические подробности
Опубликовано в: :J Exp Clin Cancer Res
Главные авторы: Wang, Chenghe, Ge, Qiangqiang, Zhang, Qingsong, Chen, Zhong, Hu, Jia, Li, Fan, Ye, Zhangqun
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2016
Предметы:
Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4807596/
https://ncbi.nlm.nih.gov/pubmed/27012825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-016-0329-8
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