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Comparison of RELMα and RELMβ Single- and Double-Gene-Deficient Mice Reveals that RELMα Expression Dictates Inflammation and Worm Expulsion in Hookworm Infection

Resistin-like molecules (RELMs) are highly expressed following helminth infection, where they impact both the host and helminth. While RELMα (Retnla) impairs helminth expulsion by inhibiting protective Th2 immunity, RELMβ (Retnlb) can promote its expulsion. We employed Retnla(−/−) and Retnlb(−/−) mi...

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Detalhes bibliográficos
Publicado no:Infect Immun
Main Authors: Chen, Gang, Wang, Spencer H., Jang, Jessica C., Odegaard, Justin I., Nair, Meera G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4807501/
https://ncbi.nlm.nih.gov/pubmed/26831469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01479-15
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