Interleukin-13 Receptor α1-Dependent Responses in the Intestine Are Critical to Parasite Clearance

Nematode infection upregulates interleukin-4 (IL-4) and IL-13 and induces STAT6-dependent changes in gut function that promote worm clearance. IL-4 and IL-13 activate the type 2 IL-4 receptor (IL-4R), which contains the IL-13Rα1 and IL-4Rα chains. We used mice deficient in IL-13Rα1 (IL-13Rα1(−/−)) t...

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Detaylı Bibliyografya
Yayımlandı:Infect Immun
Asıl Yazarlar: Sun, Rex, Urban, Joseph F., Notari, Luigi, Vanuytsel, Tim, Madden, Kathleen B., Bohl, Jennifer A., Ramalingam, Thirumalai R., Wynn, Thomas A., Zhao, Aiping, Shea-Donohue, Terez
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2016
Konular:
Host Response and Inflammation
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4807467/
https://ncbi.nlm.nih.gov/pubmed/26810038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00990-15
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