Mitigation of NADPH Oxidase 2 Activity as a Strategy to Inhibit Peroxynitrite Formation

Using high throughput screening-compatible assays for superoxide and hydrogen peroxide, we identified potential inhibitors of the NADPH oxidase (Nox2) isoform from a small library of bioactive compounds. By using multiple probes (hydroethidine, hydropropidine, Amplex Red, and coumarin boronate) with...

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Vydáno v:J Biol Chem
Hlavní autoři: Zielonka, Jacek, Zielonka, Monika, VerPlank, Lynn, Cheng, Gang, Hardy, Micael, Ouari, Olivier, Ayhan, Mehmet Menaf, Podsiadły, Radosław, Sikora, Adam, Lambeth, J. David, Kalyanaraman, Balaraman
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2016
Témata:
Molecular Biophysics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4807286/
https://ncbi.nlm.nih.gov/pubmed/26839313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.702787
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