Targeting Oncogenes into a Defined Subset of Mammary Cells Demonstrates That the Initiating Oncogenic Mutation Defines the Resulting Tumor Phenotype

Breast cancers exhibit high intertumoral heterogeneity in genetic alterations as well as histopathological and other phenotypic characteristics. The contribution of the initiating oncogenic mutation to tumor phenotype remains controversial, largely due to the technical difficulties in delivering gen...

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Detalhes bibliográficos
Publicado no:Int J Biol Sci
Main Authors: Holloway, Kimberly R., Sinha, Vidya C., Bu, Wen, Toneff, Michael, Dong, Jie, Peng, Yi, Li, Yi
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4807158/
https://ncbi.nlm.nih.gov/pubmed/27019623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.12947
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