Single Low Dose Primaquine (0.25mg/kg) Does Not Cause Clinically Significant Haemolysis in G6PD Deficient Subjects

BACKGROUND: Primaquine is the only drug consistently effective against mature gametocytes of Plasmodium falciparum. The transmission blocking dose of primaquine previously recommended was 0.75mg/kg (adult dose 45mg) but its deployment was limited because of concerns over haemolytic effects in patien...

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Udgivet i:PLoS One
Main Authors: Bancone, Germana, Chowwiwat, Nongnud, Somsakchaicharoen, Raweewan, Poodpanya, Lalita, Moo, Paw Khu, Gornsawun, Gornpan, Kajeechiwa, Ladda, Thwin, May Myo, Rakthinthong, Santisuk, Nosten, Suphak, Thinraow, Suradet, Nyo, Slight Naw, Ling, Clare L., Wiladphaingern, Jacher, Kiricharoen, Naw Lily, Moore, Kerryn A., White, Nicholas J., Nosten, Francois
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4807095/
https://ncbi.nlm.nih.gov/pubmed/27010542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0151898
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