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Human T-cell receptor (TCR) alpha/beta + CD4-CD8- T cells express oligoclonal TCRs, share junctional motifs across TCR V beta-gene families, and phenotypically resemble memory T cells.

Most human T cells express the TCR alpha/beta and either CD4 or CD8 molecules (single positive, SP); however, small numbers lack CD4 and CD8. In inbred mice, alpha/beta CD4-CD8- (double negative, DN) T cells preferentially express certain beta variable region (V beta) families and may arise via uniq...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Brooks, E G, Balk, S P, Aupeix, K, Colonna, M, Strominger, J L, Groh-Spies, V
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1993
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC48069/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7505446/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.24.11787
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