A rationally-designed chimeric KDM1A/KDM1B histone demethylase tower domain deletion mutant retaining enzymatic activity

A target with therapeutic potential, lysine-specific demethylase 1A (KDM1A) is a regulator of gene expression whose tower domain is a protein–protein interaction motif. This domain facilitates the interaction of KDM1A with coregulators and multiprotein complexes that direct its activity to nucleosom...

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Gepubliceerd in:FEBS Lett
Hoofdauteurs: Burg, Jonathan M., Makhoul, Alan T., Pemble, Charles W., Link, Jennifer E., Heller, Frederick J., McCafferty, Dewey G.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4806859/
https://ncbi.nlm.nih.gov/pubmed/26226427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2015.07.028
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