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Measurement of Gene Regulation in Individual Cells Reveals Rapid Switching Between Promoter States
In vivo mapping of transcription-factor binding to the transcriptional output of the regulated gene is hindered by probabilistic promoter occupancy, the presence of multiple gene copies, and cell-to-cell variability. We demonstrate how to overcome these obstacles in the lysogeny maintenance promoter...
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| Udgivet i: | Science |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4806797/ https://ncbi.nlm.nih.gov/pubmed/26965629 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad0635 |
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