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Impact of Phenotype Definition on Genome-Wide Association Signals: Empirical Evaluation in Human Immunodeficiency Virus Type 1 Infection

Discussion on improving the power of genome-wide association studies to identify candidate variants and genes is generally centered on issues of maximizing sample size; less attention is given to the role of phenotype definition and ascertainment. The authors used genome-wide data from patients infe...

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Detalhes bibliográficos
Publicado no:Am J Epidemiol
Main Authors: Evangelou, Evangelos, Fellay, Jacques, Colombo, Sara, Martinez-Picado, Javier, Obel, Niels, Goldstein, David B., Telenti, Amalio, Ioannidis, John P. A.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4806701/
https://ncbi.nlm.nih.gov/pubmed/21490045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/aje/kwr024
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