Sorcin Links Pancreatic β-Cell Lipotoxicity to ER Ca(2+) Stores

Preserving β-cell function during the development of obesity and insulin resistance would limit the worldwide epidemic of type 2 diabetes. Endoplasmic reticulum (ER) calcium (Ca(2+)) depletion induced by saturated free fatty acids and cytokines causes β-cell ER stress and apoptosis, but the molecula...

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Publicado en:Diabetes
Autores principales: Marmugi, Alice, Parnis, Julia, Chen, Xi, Carmichael, LeAnne, Hardy, Julie, Mannan, Naila, Marchetti, Piero, Piemonti, Lorenzo, Bosco, Domenico, Johnson, Paul, Shapiro, James A.M., Cruciani-Guglielmacci, Céline, Magnan, Christophe, Ibberson, Mark, Thorens, Bernard, Valdivia, Héctor H., Rutter, Guy A., Leclerc, Isabelle
Formato: Artigo
Lenguaje:Inglês
Publicado: American Diabetes Association 2016
Materias:
Islet Studies
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4806657/
https://ncbi.nlm.nih.gov/pubmed/26822088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db15-1334
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