Drug Repurposing Screen Identifies Foxo1-Dependent Angiopoietin-2 Regulation in Sepsis

OBJECTIVE: The recent withdrawal of a targeted sepsis therapy has diminished pharmaceutical enthusiasm for developing novel drugs for the treatment of sepsis. Angiopoietin-2 is an endothelial-derived protein that potentiates vascular inflammation and leak-age and may be involved in sepsis pathogenes...

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Publicado no:Crit Care Med
Main Authors: Ghosh, Chandra C., Thamm, Kristina, Berghelli, Anthony V., Schrimpf, Claudia, Maski, Manish R., Abid, Tanaz, Milam, Katelyn E., Rajakumar, Augustine, Santel, Ansgar, Kielstein, Jan T., Ahmed, Asif, Thickett, David, Wang, Keqin, Chase, Maureen, Donnino, Michael W., Aird, William C., Haller, Hermann, David, Sascha, Parikh, Samir M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4806531/
https://ncbi.nlm.nih.gov/pubmed/25855898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CCM.0000000000000993
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