Loss of MYO5B in Mice Recapitulates Microvillus Inclusion Disease and Reveals an Apical Trafficking Pathway Distinct to Neonatal Duodenum

BACKGROUND & AIMS: Inactivating mutations in myosin Vb (MYO5B) cause severe neonatal diarrhea in microvillus inclusion disease. Loss of active MYO5B causes the formation of pathognomonic inclusions and aberrations in brush-border enzymes. METHODS: We developed 3 mouse models of germline, constit...

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Gepubliceerd in:Cell Mol Gastroenterol Hepatol
Hoofdauteurs: Weis, Victoria G., Knowles, Byron C., Choi, Eunyoung, Goldstein, Anna E., Williams, Janice A., Manning, Elizabeth H., Roland, Joseph T., Lapierre, Lynne A., Goldenring, James R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2015
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Original Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4806369/
https://ncbi.nlm.nih.gov/pubmed/27019864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2015.11.009
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