Myosin Vb uncoupling from RAB8A and RAB11A elicits microvillus inclusion disease

Microvillus inclusion disease (MVID) is a severe form of congenital diarrhea that arises from inactivating mutations in the gene encoding myosin Vb (MYO5B). We have examined the association of mutations in MYO5B and disruption of microvillar assembly and polarity in enterocytes. Stable MYO5B knockdo...

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Detalhes bibliográficos
Main Authors: Knowles, Byron C., Roland, Joseph T., Krishnan, Moorthy, Tyska, Matthew J., Lapierre, Lynne A., Dickman, Paul S., Goldenring, James R., Shub, Mitchell D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4071383/
https://ncbi.nlm.nih.gov/pubmed/24892806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI71651
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