A novel ciprofloxacin-resistant subclade of H58 Salmonella Typhi is associated with fluoroquinolone treatment failure

The interplay between bacterial antimicrobial susceptibility, phylogenetics and patient outcome is poorly understood. During a typhoid clinical treatment trial in Nepal, we observed several treatment failures and isolated highly fluoroquinolone-resistant Salmonella Typhi (S. Typhi). Seventy-eight S....

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Gepubliceerd in:eLife
Hoofdauteurs: Pham Thanh, Duy, Karkey, Abhilasha, Dongol, Sabina, Ho Thi, Nhan, Thompson, Corinne N, Rabaa, Maia A, Arjyal, Amit, Holt, Kathryn E, Wong, Vanessa, Tran Vu Thieu, Nga, Voong Vinh, Phat, Ha Thanh, Tuyen, Pradhan, Ashish, Shrestha, Saroj Kumar, Gajurel, Damoder, Pickard, Derek, Parry, Christopher M, Dougan, Gordon, Wolbers, Marcel, Dolecek, Christiane, Thwaites, Guy E, Basnyat, Buddha, Baker, Stephen
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: eLife Sciences Publications, Ltd 2016
Onderwerpen:
Epidemiology and Global Health
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4805543/
https://ncbi.nlm.nih.gov/pubmed/26974227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.14003
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